As Monsanto’s patent for Aspartame was nearing expiration, they developed the strategy of adding a hazardous chemical to to it, making it sweeter, and more toxic, and calling it Neotame. There was no trouble in getting FDA approval, which then also waived labeling requirements.

Even Monsanto’s own pre-approval studies of neotame revealed adverse reactions. Unfortunately, Monsanto only conducted a few one-day studies in humans rather than encouraging independent researchers to obtain NIH funding to conduct long-term human studies on the effects of neotame.